刘月涛，男，博士，教授，博士生导师。1984年出生，山西省怀仁人。2014年于北京协和医学院药用植物研究所获得医学博士学位。2014年7月至今在山西大学中医药现代研究中心工作。承担国家自然科学基金青年基金和面上项目共3项，山西省青年科技研究基金1项, 山西省高等教育科技创新项目1项。授权发明专利3件，以第一作者或通讯作者发表研究论文65篇，其中SCI收录43篇。兼任中国康复医学会中药学与康复专业委员会委员、中国药理学会心血管药理专委会青年委员会常务委员、山西省药理学会药物代谢组学专业委员会常务委员、《中草药》杂志青年编委等。2018年被评为山西省“三晋英才”青年优秀人才称号。
研究方向：
中药药效物质基础与作用机制研究&中医药代谢组学研究
博士招生专业：
本草生物学
硕士招生专业：
药学、中药学（专业学位）
研究生培养情况：
正在培养博士生2名，硕士研究生10名，已毕业硕士研究生14名：
[1] 崔佳佳，黄芪建中汤防治慢性萎缩性胃炎的代谢机制研究（2017）；
[2] 胡英还，黄芪建中汤体内外化学成分研究（2018）；
[3] 许文倩，黄芪对黄芪建中汤干预慢性萎缩性胃炎的贡献及定向药效成分研究（2019）；
[4] 贾璐，黄芪建中汤化学成分体内代谢研究（2020）；
[5] 薛倩倩，基于黄芪-丹参药对配伍研究不同种植方式黄芪的化学成分及其药效差异（2020）；
[6] 李鑫琦，仿野生与平栽黄芪配伍的当归补血汤药效与配伍的机制比较研究（2020）；
[7] 张冬，基于诊断离子技术的黄芪-丹参药对体内外化学成分分析（2021）；
[8] 胡静，基于UPLC-Q-TOF-MS结合诊断离子与分子网络策略解析当归补血汤的化学成分（2021）；
[9] 靳志东，仿野生和平栽黄芪配伍的黄芪建中汤治疗慢性萎缩性胃炎的“代谢—肠道菌群”研究（2021）；
[10] 王子莹，桂枝与肉桂水提物的化学成分及其干预慢性萎缩性胃炎的药效比较研究（2022）；
[11] 李丹，基于代谢组学的仿野生和平栽黄芪的化学成分变化规律研究（2022）；
[12] 蔡聪聪，玉郎伞多糖对慢性应激抑郁大鼠代谢和肠道菌群的调控作用研究（2023）；
[13] 范凯迪，基于“微生物-脑-肠”轴的黄芪丹参药对干预局部脑缺血大鼠的作用机制研究（2022）；
[14] 廉旭，基于胃肠微生物调控的小建中汤治疗慢性萎缩性胃炎大鼠的作用机制研究（2023）。
[15] 张若男，基于肠道菌群的黄芪建中汤治疗慢性萎缩性胃炎机制研究（2024）。
[16] 崔晓静，多种策略整合的小建中汤化学成分表征与潜在成分预测（2024）。
[17] 刘玉碟，基于胃黏膜菌群研究黄芪和蜜炙黄芪干预慢性萎缩性胃炎大鼠的物质基础（2024）。
[18] 向若歆，基于血清药物化学和代谢组学探究小建中汤干预慢性萎缩性胃炎大鼠的配伍机制（2024）。
[19] 张辉，基于粪菌移植、代谢组学和16s rRNA测序技术探究小建中汤干预慢性萎缩性胃炎大鼠的配伍机制（2024）
主要科研项目：
[1] 主持国家自然科学基金面上项目（82374025）：靶向“胃黏膜菌群-脑肠肽”互作研究黄芪干预慢性萎缩性胃炎伴情绪障碍的物质基础和作用机制，直接经费：49万元，202401-202712（在研）.
[2] 主持国家自然科学基金面上项目（82073988）：基于线粒体-肠道菌群交互作用研究小建中汤温中补虚作用的配伍规律和物质基础，直接经费：55万元，202101-202412（在研）。
[3] 主持国家自然科学基金青年基金项目（81703697）：基于“组-效-动”三元定向关联的黄芪“益气建中”功效的质量标志物研究，直接经费：20万元，201801-202012（已结题）。
[4] 主持山西省高等教育科技创新项目（2019L0010）：以线粒体为靶点的黄芪治疗慢性萎缩性胃炎的药效成分和代谢调控机制研究，经费：3万元，201901-202012（已结题）。
[5] 主持山西省省青年科技研究基金项目（2015021193）：基于代谢网络的黄芪建中汤防治慢性萎缩性胃炎的作用机制研究，经费：3万元，201501-201812（已结题）。
发明专利：
[1]刘月涛, 崔佳佳, 仝家羽, 等. 一种慢性萎缩性胃炎大鼠模型的评价方法. ZL201610141242.1.（已授权）
[2]刘月涛, 胡英还, 秦雪梅, 张丽增. 一种黄芪建中丸指纹图谱的构建方法. ZL201710354013.2.（已授权）
[3]秦雪梅，李鑫琦，刘月涛. 一种血虚小鼠模型的构建及评价方法. ZL201710354013.2.（已授权）
发表论文：
(1) Xiaojing Cui, Pingping Liu, Xingyue Huang, Yongjie Yu, Xuemei Qin, Huina Zhou, Qingxia Zheng*, Yuetao Liu*. Enhancing coverage of annotated compounds in traditional Chinese medicine formulas: Integrating MSE and Fast-DDA molecular network with AntDAS-Case study of Xiao Jian Zhong Tang. Journal of Chromatography A, 2024, 1738, 465498. (2区TOP)
(2) Jun Jie Guo, Wen Tian Lu, Yue Tao Liu.Study on the metabolism of Xiao-Jian-Zhong-Tang in rats with chronic atrophic gastritis coupled with bioinformatics. Biomedical Chromatography. 2024, 38, e6014. (4区)
(3) Ruonan Zhang, Xuemei Qin,* Yuetao Liu*. Exploration of the intestinal flora to reveal the important contribution of Radix Astragali to Huangqi Jianzhong Tang in treating chronic atrophic gastritis rats. Journal of Pharmaceutical and Biomedical Analysis, 2024, 242, 116067. (3区)
(4) Xu Lian#, Kaidi Fan#, Xuemei Qin,* Yuetao Liu*. Amalgamated pharmacoinformatics study to investigate the mechanism of Xiao Jianzhong Tang against chronic atrophic gastritis. Current Computer-Aided Drug Design, 2024, 20, 598-615. (2区)
(5) Yuetao Liu#*, Yudie Liu#, Jing Hu, Xiaojing Cui, Xuemei Qin. Integration of diagnostic ions, molecular network and chemometrics to illustrate the chemical mechanism of Radix Astragali processed with honey. Journal of Chromatography A. 2023, 1709: 464381. (2区TOP)
(6) Yuetao Liu#*, Ruoxin Xiang#, Wentian Lu, Xuemei Qin*. Symptom-oriented network pharmacology revealed the mechanism of HuangQi-DanShen herb pair against cerebral ischemia coupled with comprehensive chemical characterization. Journal of Ethnopharmacology. 2024, 318: 116845. (2区TOP)
(7) Yuetao Liu*, Hui Zhang, Wentian Lu, Tao Jiang*. Integrating metabolomics, 16S rRNA sequencing, network pharmacology, and metorigin to explore the mechanism of Cinnamomi Cortex in treating chronic atrophic gastritis rats. Phytomedicine. 2023, 121: 155084. (1区TOP)
(8) Xiaojing Cui, Xuemei Qin, Guanhua Du*, Yuetao Liu*. Rapid chemical characterization of Danggui Buxue decoction using processed Astragali Radix and Angelicae Sinensis Radix based on diagnostic ion and molecular network. Biomedical Chromatography. 2023, 37: e5640. (4区)
(9) Hui Zhang, Xingyue Huang, Guohong Wang*, Yuetao Liu*. Huangqi Jianzhong Tang treats chronic atrophic gastritis rats by regulating intestinal flora and conjugated bile acid metabolism. Biomedical Chromatography. 2023, 37: e5721. (4区)
(10) Yuetao Liu#*, Xu Lian#, Xuemei Qin*. Bile acid metabolism involved into the therapeutic action of Xiaojianzhong Tang via gut microbiota to treat chronic atrophic gastritis in rats. Phytomedicine, 2023, 109: 154557. (1区TOP)
(11) Dan Li, Yuetao Liu*, Xuemei Qin*. Rapid quantitative analysis of 12 chemical constituents in wild-simulated and cultivated Astragali Radix based on UHPLC-MS. Chinese Herbal Medicines, 2022, 14: 464-469.
(12) Yuetao Liu*, Congcong Cai, Xuemei Qin*. Regulation of gut microbiota of Astragali Radix in treating for chronic atrophic gastritis rats based on metabolomics coupled with 16S rRNA gene sequencing. Chemico-Biological Interactions, 2022, 365: 110063. (2区)
(13) Yuetao Liu*, Kaidi Fan, Longfei Yang, Xuemei Qin*. Comparison of the efficacies of Huangqi-Danshen herbal pair compatibility with wild-simulated and transplanted Astragali Radix based on a novel metabolomics strategy. Chemometrics and Intelligent Laboratory Systems, 2022, 230: 104658. (3区)
(14) Lu Jia, Xuemei Qin*, Yuetao Liu*. Integrated pharmacokinetics of Huangqi Jianzhong Tang in normal and chronic atrophic gastritis rats. Biomedical Chromatography, 2022, e5492. (4区)
(15) Lu Jia, Xuemei Qin*, Yuetao Liu*. Metabolite identification of Huangqi Jianzhong Tang in rat urine and feces after oral administration based on UHPLC-Q-Exactive-MS. Journal of Chromatographic Science, 2022, 1-14. (4区)
(16) YueTao Liu*, Yanhong Ju; XueMei Qin. * Studies on the compatibility mechanism and material basis of Danggui Buxue Decoction against anemia mice using metabonomics and network pharmacology, Journal of Pharmacy and Pharmacology, 2021, 73: 767-777. (3区)
(17) YueTao Liu*, ZiYing Wang, Xuemei Qin*. Metabolomics and molecular docking to compare of the efficacies of wild-simulated and transplanted Astragali Radix based on its compatibility with Angelicae Sinensis Radix against blood deficiency, Journal of Chromatography B, 2021, 1173: 122683. (3区)
(18) QianQian Xue#, Liang Chen#, XueMei Qin*, YueTao Liu*. Integrated metabonomics and serum pharmacochemistry strategy for ascertaining the material basis of Huangqi Jianzhong Tang against chronic atrophic gastritis, Chemometrics and Intelligent Laboratory Systems, 2021, 210: 104254. (3区)
(19) Dong Zhang#, Liang Chen#, XueMei Qin*, YueTao Liu*. Mitochondria metabonomics of Huangqi Jianzhong Tang against chronic atrophic gastritis, Biomedical Chromatography, 2020, 35(3): e5013. (3区)
(20) Yuetao Liu*, Xinqi Li, Xuemei Qin*. Saccharum Granorum ameliorated mitochondrial dysfunction in chronic atrophic gastritis rats using organelle-specific metabolomics and network pharmacology approaches. Food Research International, 2020, 136: 109503. (2区)
(21) WenQian Xu, Xuemei Qin*, Yuetao Liu*. Network pharmacology research of Astragali Radix in treating chronic atrophic gastritis rats based on mitochondrial metabonomics. Journal of Chromatography B, 2020, 1145: 122109. (3区)
(22) YueTao Liu*, XinQi Li, AiPing Li, Ke Li, XueMei Qin*. UHPLC Q-Exactive MS-based spleen metabolomics and lipidomics to explore the effect mechanisms of Danggui Buxue Decoction in anemia mice. Journal of Pharmaceutical and Biomedical Analysis, 2020, 185: 113234. (3区)
(23) YueTao Liu*, QianQian Xue, AiPing Li, Ke Li, XueMei Qin*. Mechanisms exploration of herbal pair of HuangQi-DanShen on cerebral ischemia based on metabonomics and network pharmacology. Journal of Ethnopharmacology, 2020, 253: 112688. (3区)
(24) Xinqi Li, Aiping Li, Ke Li, Xuemei Qin*, Yuetao Liu*. Metabonomics approach reveals the vital role of Huangqi in Huangqi Jianzhong Tang against chronic atrophic gastritis coupled with molecular docking and BAWP. Chemometrics and Intelligent Laboratory Systems, 2020, 200: 103984. (3区)
(25) Yuetao Liu*, Zhidong Jin, Xuemei Qin, Qingxia Zheng*. Urinary metabolomics research for Huangqi Jianzhong Tang against chronic atrophic gastritis rats based on 1H NMR and UPLC-Q/TOF MS. Journal of Pharmacy and Pharmacology, 2020, 72: 748-760. (3区)
(26) Guohong Wang, Xuemei Qin*, Yuetao Liu*. Role of Saccharum Granorum as a “Principal Drug” in a traditional Chinese medicine formula against chronic atrophic gastritis rats. Pharmacognosy Magazine, 2020, 16: 43-50. (4区)
(27) Yuetao Liu*, Lu Jia, Xuemei Qin*. Rapid quantitative analysis of eighteen chemical constituents in HuangQi JianZhong Tang based on UHPLC-MS. Biomedical Chromatography, 2020, 34(3): e4754. (4区)
(28) Yuetao Liu*, Wenxian Xu, Xuemei Qin*. Deciphering the mechanical network of chronic atrophic gastritis: a urinary time-dependent metabonomics-based network pharmacology study. Frontiers in Physiology, 2019, 10: 1004. (2区)
(29) Yuetao Liu*, Wenqian Xu, Guohong Wang, Aiping Li, Ke Li, Xuemei Qin*. The comparison of serum and plasma specimens in NMR-based metabonomics and its application on chronic atrophic gastritis rat. Analytical Methods, 2019, 11: 2018-2026. (3区)
(30) Yuetao Liu*, Lu Jia, Aiping Li, Ke Li, Xuemei Qin*. Metabolite analysis of Huangqi Jianzhong Tang using UHPLC-Q-Exactive-MS in rat plasma. Journal of Liquid Chromatography & Related Technologies, 2019, 42(17-18): 593-604. (4区)
(31) Yuetao Liu*, Yinghuan Hu, Guohong Wang, Aiping Li, Ke Li, Qingxia Zheng*, Xuemei Qin*. Huangqi Jianzhong Tang ameliorated phospholipase A2 and glycerophospholipids metabolism against chronic atrophic gastritis rats. Journal of Liquid Chromatography & Related Technologies, 2018, 41(19-20): 1082-1091.
(32) Yuetao Liu*, Wenqian Xu, Yifeng Xiong, Guanhua Du, Xuemei Qin*. Evaluations of the effect of Huangqi against heart failure based on comprehensive echocardiography index and metabonomics. Phytomedicine, 2018, 50: 205-212. (3区TOP)
(33) Yuetao Liu*, Wenqian Xu, Guohong Wang, Xuemei Qin*. Material basis research for Huangqi Jianzhong Tang against chronic atrophic gastritis rats through integration of urinary metabonomics and SystemsDock. Journal of Ethnopharmacology, 2018, 223: 1-9. (3区)
(34) Lin Chen#, Yuetao Liu#, Qingfeng Guo, Qingxia Zheng*, Wancun Zhang*. Metabolomic comparison between wild Ophiocordyceps sinensis and artificial cultured Cordyceps militaris. Biomedical Chromatography, 2018, 32(9); e4279.（并列第一）(4区)
(35) Jiajia Cui, Yuetao Liu*, Yinghuan Hu, Jiayu Tong, Aiping Li, Tingli Qu, Xuemei Qin, Guanhua Du*. NMR-based metabonomics and correlation analysis reveal potential biomarkers associated with chronic atrophic gastritis. Journal of Pharmaceutical and Biomedical Analysis, 2017, 132: 77-86. (3区)
(36) Yuetao Liu*, Jiajia Cui, Yinghuan Hu, Guanhua Du, Xuemei Qin*. Integrating untargeted metabonomics, partial least square regression analysis and MetPA to explore the targeted pathways involved into Huangqi Jiangzhong Tang against chronic atrophic gastritis rats. Chemometrics and Intelligent Laboratory Systems, 2017, 164: 16-25. (2区)
(37) Yuetao Liu, Chao Zhou, Hongmei Jia, Xing Chang, Zhongmei Zou*. Standardized Chinese Formula Xin-Ke-Shu inhibits the myocardium Ca2+ overloading and metabolic alternations in isoproterenol-induced myocardial infarction rats. Scientific Reports, 2016, 6: 30208. (3区)
(38) Yuetao Liu, Hongmei Jia, Xing Chang, Weihua Cheng, Xin Zhao, Gang Ding, Hongwu Zhang, Dayong Cai*, Zhongmei Zou*. Metabolic pathways involved in Xin-Ke-Shu protecting against myocardial infarction in rats using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2014, 90: 35-44. (3区)
(39) Yuetao Liu, Jingbo Peng, Hongmei Jia, Dayong Cai, Hongwu Zhang, Changyuan Yu*, Zhongmei Zou*. UPLC-Q/TOF MS standardized Chinese Formula Xin-Ke-Shu for the treatment of atherosclerosis in a rabbit model. Phytomedicine, 2014, 21: 1364-1372.(3区)
(40) Yuetao Liu, Jingbo Peng, Hongmei Jia, Hongwu Zhang, Gang Ding, Zhongmei Zou*. Urinary metabonomic evaluation of the therapeutic effect of traditional Chinese medicine Xin-Ke-Shu against atherosclerosis rabbits using UPLC-Q/TOF MS. Chemometrics and Intelligent Laboratory Systems, 2014, 136: 104-114. (2区)
(41) Yuetao Liu, Hongmei Jia, Xing Chang, Gang Ding, Hongwu Zhang, Zhongmei Zou*. The metabolic disturbances of isoproterenol induced myocardial infarction in rats based on a tissue targeted metabonomics. Molecular BioSystems, 2013, 9: 2823-2834. (3区)
(42) Yuetao Liu, Binan Lu, Jinyong Peng*. Hepatoprotective activity of the total flavonoids from Rosa laevigata Michx fruit in mice treated by paracetamol. Food Chemistry, 2011, 125: 719-725. (3区)
(43) Lina Xu, Yuetao Liu, Tie Wang, Yan Qi, Xu Han, Youwei Xu, Jinyong Peng*, Xinqiang Tang. Development and validation of a sensitive and rapid non-aqueous LC-ESI-MS/MS method for measurement of diosgenin in the plasma of normal and hyperlipidemic rats. Journal of Chromatography B, 2009, 877: 1530-1536.（并列第一）(3区)
(44) 黄欣悦, 秦雪梅, 刘月涛*. 线粒体代谢组学及其在中医药研究中的进展. 神经药理学报, 2024, 14(3): 59-64.
(45) 郭俊杰, 秦雪梅, 刘月涛*. 肠道细菌介导中药代谢的研究概述. 药学学报. 2024, 59(4): 831−839.
(46) 卢文天, 刘月涛*, 秦雪梅. 胆汁酸参与慢性萎缩性胃炎的致病机制及其中药干预的研究进展. 神经药理学报, 2023, 13(2): 46-51.
(47) 刘玉碟,秦雪梅, 刘月涛*. 脱氧胆酸靶点参与多种疾病发病机制的研究进展. 药物评价研究, 2023, 46(4): 905-910.
(48) 崔晓静, 张辉, 刘月涛*，秦雪梅*. 肠道菌群孵育技术及其在中药分析中的应用研究进展. 分析测试学报, 2023, 42(8): 1072-1078.
(49) 张辉, 秦雪梅*, 刘月涛*. 肠道菌群代谢物对肠道上皮细胞线粒体的调控机制及中药干预研究进展. 药学学报, 2022, 57(12): 3487-3493.
(50) 王国宏，贾璐，王世伟*，刘月涛*. 黄芪建中汤在大鼠胆汁中代谢产物的鉴定. 中草药, 2021, 52(19): 5827-5835.
(51) 张冬, 李爱平, 李科, 刘月涛*, 秦雪梅*. 黄芪丹参药对配伍机制的研究进展, 山西中医药大学学报, 2021, 22(1): 70-74.
(52) 胡静, 李科, 李爱平, 刘月涛*, 秦雪梅*. 当归补血汤物质基础研究进展. 中草药, 2020, 51(21): 5653-5663.
(53) 李丹, 李爱平, 李科, 刘月涛*, 秦雪梅*. 液质联用技术在中药化学成分定性分析中的研究进展, 药物评价研究, 2020, 43(10): 2112-2119.
(54) 薛倩倩, 李爱平, 李科, 刘月涛*, 秦雪梅*. 黄芪的质量评价研究概述及质量标志物研究策略初探, 药物评价研究, 2019, 42(12): 2459-2463
(55) 李鑫琦, 高耀, 李爱平, 李科, 刘月涛*, 秦雪梅. 含黄芪方剂组方规律及核心药对“黄芪-当归”分子机制的研究. 中草药, 2019, 50(20): 5273-5281.
(56) 靳志东, 李科, 李爱平, 秦雪梅, 刘月涛*. 黄芪建中汤及其组方单味药化学成分与体内代谢研究进展. 中草药, 2019, 50(18): 4495-4501.
(57) 薛倩倩, 秦雪梅, 刘月涛*. 基于尿液动态轨迹分析的慢性萎缩性胃炎生物标志物的筛选. 中国药学杂志, 2019, 54(14): 1148-1153.
(58) 刘月涛*, 胡英还, 秦雪梅*. 黄芪建中汤治疗大鼠慢性萎缩性胃炎的代谢组学研究.中草药, 2018, 49(10): 2312-2319.
(59) 许文倩, 秦雪梅*, 刘月涛*. 基于网络药理学的黄芪建中汤治疗慢性萎缩性胃炎作用机制研究.中草药, 2018, 49(15): 3550-3561.
(60) 刘月涛*, 贾璐, 秦雪梅*. 多效黄芪物质基础的研究进展. 中草药, 2018, 49(6): 1476-1480.
(61) 刘月涛*, 胡英还, 秦雪梅. 非靶标代谢组学研究的影响因素分析. 药物分析杂志, 2019, 39(1): 89-93.
(62) 薛倩倩, 刘晓节, 李科, 李爱平, 秦雪梅*, 刘月涛*. 黄芪药材化学成分差异的研究进展. 山西医科大学学报, 2018, 49(10): 1259-1263.
(63) 胡英还, 许文倩, 秦雪梅*, 刘月涛*. UHPLC-Q Exactive轨道肼高分辨质谱在线快速识别黄芪建中汤的化学成分. 药学学报, 2017, 52(6): 964-970.
(64) 崔佳佳, 胡英还, 秦雪梅, 杜冠华, 刘月涛*. 血清胃蛋白酶原检测在慢性萎缩性胃炎早期筛查中的价值分析. 山西医科大学学报, 2016, 47: 1127-1130.
(65) 许文倩, 胡英还, 秦雪梅, 刘月涛*. 黄芪建中汤临床应用及实验研究进展. 山西中医学院学报, 2018, 19(1): 66-71.
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