高丽，博士，副教授，硕士生导师，“三晋英才”青年优秀人才，研究方向为神经药理学及抗衰老研究。主持国家自然科学青年基金1项、中国博士后科学基金面上项目1项、山西省重点研发计划（社发领域）项目1项、其他省部级项目5项，以第一作者和通讯作者发表学术论文30余篇，SCI论文28篇,其中SCI一区论文2篇，SCI二区论文14篇，代表性杂志Ageing Research Reviews （IF:13.1）、Phytomedicine（IF: 7.9）、ACS chemical neuroscience等。兼任中国药理学会网络药理学专业委员会委员，中国药理学会中药及天然药物委员会委员，中国研究型医院学会神经再生与修复专业委员会委员。
工作经历：
2017/12-至今：山西大学中医药现代研究中心，副教授
2014/07-2017/12: 山西大学中医药现代研究中心，讲师
教育经历：
2009/09—2014/07: 北京协和医学院药物研究所，药理学专业，硕博连读，导师：杜冠华教授 刘艾林教授
2005/09-2009/07: 沈阳药科大学，药学院，药学专业，理学学士
研究方向：神经药理学、抗衰老研究
硕士招生专业：药学、中药学
联系方式：Email: gaoli87@sxu.edu.cn 电话：13623639072
承担科研项目（主持）：
(1) 国家自然科学青年基金，81603319，基于基因网络调控的黄芩素改善衰老性学习记忆障碍作用机制研究，2017.01-2019.12，经费18万，结题，主持。
(2) 中国博士后科学基金第72批面上项目，基于钠离子通道 Nav1.7 研究复方苦参注射液治疗癌性疼痛的显效成分和作用机制，2023.1-2024.12，经费8万元，在研，主持。
(3) 山西省基础研究计划自然科学研究面上项目，基于基因调控布尔网络研究黄芩素抑制衰老相关分泌表型（SASP）改善衰老性认知功能障碍的机制，2023.1-2025.12，经费10万元，在研，主持。
(4) 山西省重点研发计划（社发领域）项目，201903D321216，经典方剂黄芩汤治疗帕金森病的新功效研发，2019.12.01-2021.12.01，经费5万，主持。
(5) 山西省面上青年基金项目，201801D221374，黄芩素调控基因网络改善SAMP8快速老化小鼠学习记忆障碍机制研究，2018.12-2020.12，经费3万，在研，主持。
(6) 山西省研究生联合培养基地人才项目，2016JD05，基于网络药理学的复方苦参注射液治疗肝癌作用机制研究，经费3万，结题，主持。
(7) 山西省高等学校科技创新项目，2015118，基于药物-靶点网络的黄芩单体成分抗衰老活性研究，2015.03-2017.03，经费3万，结题，主持。
(8) 山西省研究生教育改革项目，2019JG029，《实验设计与医药统计》教学改革与实践探索，2019.07.01-2022.06.22，经费1万，结题，主持。
(9) 横向项目，基于代谢组学研究丹酚酸A防治脑缺血的作用及机制，5万元，2021.01-2022.12，在研，主持。
(10) 横向项目，基于代谢组学研究中药复方防治脑病的作用及机制，7.5万元，2021.01-2022.12，在研，主持
专著：
[1] 杜冠华译，王月华，刘艾林, 高丽（参编）. 药理学原理，人民卫生出版社, 2023.
[2] 杜冠华, 陈乃宏, 陈忠, 方莲花, 秦雪梅, 高丽（参编）. 实验药理学，高等教育出版社, 2021.
[3] 黄璐琦, 屠鹏飞, 高晓燕，张媛，秦雪梅，高丽（参编）. 新编中国药材学， 中国医药科技出版社，2020.
[4] 杜冠华, 张均田, 方莲花, 吕扬, 陈乃宏, 王金华, 秦雪梅, 高丽（参编）. 天然小分子药物, 人民卫生出版社, 2018.
[5] 王喜军，韩莹，孙晖，闫广利，秦雪梅，高丽（参编）. 中医方证代谢组学研究进展, 科学出版社, 2018.
获奖：
[1] 王秀伶，于秀梅，赵慧，梁晓琳，高丽. 大豆异黄酮微生物转化产物的有氧合成调控及其抗癌作用机制，河北省自然科学三等奖，2021.
代表性论文：
[1] Yi-xiao Dong, Kun-kun Zhao, Xue-mei Qin, Guanhua-Du*, Li Gao*. The mechanisms of perineuronal net abnormalities in contributing aging and neurological diseases. Ageing Research Reviews. 2023, 92:102092. (SCI 1区，TOP，IF：13.1）
[2] Li Gao*, Wu-yan Yang, Hong Qi, Chang-jun Sun, Xue-mei Qin, Guan-hua Du*. Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low glucose-induced astrocytes based on boolean network. Phytomedicine, 2022, 99:153990. （SCI 2区，TOP）
[3] Li Gao*, Min Cao, Guan-hua Du, Xue-mei Qin*. Huangqin Decoction Exerts Beneficial Effects on Rotenone-Induced Rat Model of Parkinson's Disease by Improving Mitochondrial Dysfunction and Alleviating Metabolic Abnormality of Mitochondria. Frontiers in Aging Neuroscience, 2022, 14: 911924. （SCI 2区）
[4] Ke-Xin Wang, Guan-hua Du, Xue-mei Qin*, Li Gao*. 1H-NMR-based metabolomics reveals the biomarker panel and molecular mechanism of hepatocellular carcinoma progression. Analytical and Bioanalytical Chemistry, 2022, 414(4): 1525-1537. (SCI 3区）
[5] Ke-Xin Wang, , Xiang-min Ye, Chuanhui Yin, Qing Ren, Yupeng Chen, Xuemei Qin, Chuanzhi Duan, Aiping Lu*, Li Gao* and Daogang Guan*. Computational Metabolomics Reveals the Potential Mechanism of Matrine Mediated Metabolic Network Against Hepatocellular Carcinoma. Frontiers In Cell And Developmental Biology, 2022, 10:859236. （SCI 2区）
[6] Ke-Xin Wang, Guan-Hua Du, Xue-Mei Qin*, Li Gao*. Compound Kushen Injection intervenes metabolic reprogramming and epithelial-mesenchymal transition of HCC via regulating β-catenin/c-Myc signaling. Phytomedicine, 2021, 93:153781. (SCI 2区，TOP，IF: 5.34)
[7] Li Gao*, Wen-ge Zheng, Xing-kang Wu, Guanhua Du, Xuemei Qin*. Baicalein Delays H2O2-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism. ACS chemical neuroscience, 2021, 12(13):2320-2335. (SCI 2区，IF: 4.42)
[8] Ke-Xin Wang, Yu-Peng Chen, Ai-Ping Lu, Guan-Hua Du, Xue-Mei Qin*, Dao-Gang Guan*, Li Gao*. A metabolic data-driven systems pharmacology strategy for decoding and validating the mechanism of Compound Kushen Injection against HCC. Journal of Ethnopharmacology, 2021, 274:114043. (SCI 3区，IF: 4.36)
[9] Ke-Xin Wang, Kai Li, Yu-Peng Chen, Gen-Xia Wei, Hai-lang Yu, Yi Li, Wei Meng, Handuo Wang , Li Gao*, Aiping Lu, Junxiang Peng, Daogang Guan. Computational Network Pharmacology-Based Strategy to Capture Key Functional Components and Decode the Mechanism of Chai-Hu-Shu-Gan-San in Treating Depression. Frontiers in Pharmacology, 2021, 12: 782060. (SCI 2区)
[10] Li Gao*, Min Cao, Jia-Qi Li, Xue-Mei Qin, Jiansong Fang*. Traditional Chinese Medicine Network Pharmacology in Cardiovascular Precision Medicine. Current Pharmaceutical Design. 2021, 27(26): 2925-2933.
[11] Jiaqi Li, Jiansong Fang, Xuemei Qin*, Li Gao*. Metabolomics profiling reveals the mechanism of caffeic acid in extending lifespan in Drosophila melanogaster. Food Funct, 2020, 11(9): 8202-8213. (SCI 1区)
[12] Kexin Wang#; Yao Gao#; Cheng Lu; Yao Li; Bo-ya Zhou; Xue-mei Qin; Guanhua Du; Li Gao*; Daogang Guan*; Ai-ping Lu*; Uncovering the Complexity Mechanism of Different Formulas Treatment for Rheumatoid Arthritis Based on a Novel Network Pharmacology Model. Front Pharmacol, 2020, 11:1035. (SCI 2区)
[13] Li Gao*, Feng Zhou, Ke-xin Wang, Yuzhi Zhou, Guanhua Du, Xuemei Qin*. Baicalein protects PC12 cells from Aβ25-35-induced cytotoxicity via inhibition of apoptosis and metabolic disorders. Life Sciences, 2020, 248:117471. (SCI 3区)
[14] Jiao-jiao Yan, Guan-hua Du, Xue-mei Qin*, Li Gao*. Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality. International Immunopharmacology, 2020, 79:106092. (SCI 3区)
[15] Ke-xin Wang, Jian-song Fang, Xue-mei Qin, Guan-hua Du⁎, Li Gao⁎, Uncovering the anti-metastasis effects and mechanisms of capsaicin against hepatocellular carcinoma cells by metabolomics. Journal of Functional Foods. 2019, 60: 103431. (SCI 2区,TOP)
[16] Jia-qi Li, Dan-dan Duan, Jian-qin Zhang, Yu-zhi Zhou, Xue-mei Qin, Guan-hua Du⁎, Li Gao⁎, Bioinformatic prediction of critical genes and pathways involved in longevity in Drosophila melanogaster. Molecular Genetics and Genomics. 2019, 294:1463–1475. (SCI 3区)
[17] Jia-qi Li, Yu-zhi Zhou, Guan-hua Du, Xue-mei Qin, Li Gao*. Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8). European Journal of Pharmacology. 2019, 865: 172789. (SCI 3区)
[18] Li Gao#*, Jia-Qi Li#, Yu-Zhi Zhou, Xu-Dong Huang, Xue-Mei Qin, Guan-Hua Du. Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8. ACS Chem Neurosci. 2018, 9(7):1714-1724. (SCI 2区,TOP)
[19] Li Gao#*, Ke-Xin Wang#, Nan-Nan Zhang#, Jia-Qi Li, Xue-Mei Qin, Xiu-Ling Wang*. 1H Nuclear Magnetic Resonance Based Metabolomics Approach Reveals the Metabolic Mechanism of (-)-5-Hydroxy-equol against Hepatocellular Carcinoma Cells in Vitro. Journal of proteome research, 2018, 17(5): 1833-1843. (SCI 2区)
[20] Li Gao#*, Ke-Xin Wang#, Yu-Zhi Zhou, Jian-Song Fang, Xue-Mei Qin*, Guan-Hua Du. Uncovering the anticancer mechanism of Compound Kushen Injection against HCC by integrating quantitative analysis, network analysis and experimental validation. Scientific reports, 2018, 8(1): 624. (SCI 3区)
[21] Jia-qi Li, Yu-zhi Zhou, Guan-hua Du, Xue-mei Qin, Li Gao*. Bioinformatic Analysis Reveals Key Genes and Pathways in Aging Brain of Senescence-accelerated Mouse P8 (SAMP8). CNS Neurol Disord Drug Targets. 2018, 17(9):712-722. (SCI 3区)
[22] Dan-Dan Duan, Ke-Xin Wang, Yu-Zhi Zhou, Xue-Mei Qin*, Li Gao*, Guan-Hua Du. Baicalein Exerts Beneficial Effects in d-Galactose-Induced Aging Rats Through Attenuation of Inflammation and Metabolic Dysfunction. Rejuvenation Research, 2017, 20(6): 506-516. (SCI 2区)
[23] Li Gao&, Xiao-Dong Wang&, Yang-Yang Niu&, Dan-Dan Duan, Xue Yang, Jian Hao, Cui-Hong Zhu, Dan Chen, Ke-Xin Wang, Xue-Mei Qin, Xiong-Zhi Wu*. Molecular targets of Chinese herbs: a clinical study of hepatoma based on network pharmacology. Scientific Reports, 2016, 6:24944. (SCI 2区)
[24] Li Gao, Dan-Dan Duan, Jian-Qin Zhang, Yu-Zhi Zhou, Xue-Mei Qin*, Guan-Hua Du*. A bioinformatic approach for discovery of the anti-aging effects of baicalein from Scutellaria baicalensis Georgi. Rejuvenation Res, 2016, 19(5): 414-422. (SCI 3区)
[25] Li Gao#, Jian Hao#, Yang-Yang Niu, Miao Tian, Xue Yang, Cui-Hong Zhu, Xiu-Li Ding, Xiao-Hui Liu, Hao-Ran Zhang, MDb, Chang Liu, Xue-Mei Qin, Xiong-Zhi Wu*. Network pharmacology dissection of multiscale mechanisms of herbal medicines in stage IV gastric adenocarcinoma treatment [J]. Medicine (Baltimore). 2016, 95(35): e4389. (SCI 2区)
[26] Li Gao, Chao Li, Ran-Yao Yang, Wen-Wen Lian, Jian-Song Fang, Xiao-Cong Pang, Xue-Mei Qin, Ai-Lin Liu*, Guan-Hua Du*. Ameliorative effects of baicalein in MPTP-induced mouse model of Parkinson's disease: A microarray study. Pharmacol Biochem Behav, 2015, 133: 155-163. (SCI 3区)
[27] Li Gao, Gang Zhao, Jian-Song Fang, Tian-Yi Yuan, Ai-Lin Liu*, Guan-Hua Du*. Discovery of the neuroprotective effects of alvespimycin by computational prioritization of potential anti-parkinson agents. FEBS Journal, 2014, 281(4): 1110-1122. (SCI 2区)
[28] Li Gao, Jian-Song Fang, Xiao-Yu Bai, Dan Zhou, Yi-Tao Wang, Ai-Lin Liu*, Guan-Hua Du*. In silico target fishing for the potential targets and molecular mechanisms of baicalein as an anti-parkinsonian agent: discovery of the protective effects on NMDA receptor-mediated neurotoxicity. Chemical Biology & Drug Design, 2013, 81(6):675-687. (SCI 3区)
[29] Li Gao, Mian Zu, Song Wu, Ai-Lin Liu*, Guan-Hua Du*. 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. Bioorganic & Medicinal Chemistry Letters, 2011, 21(19): 5964-5970. (SCI 3区)
培养研究生情况:
目前累计培养研究生10余名，其中毕业6人，在读6人。1名硕士转博，目前已博士毕业（王珂欣），1名硕士毕业后被澳门科技大学录取攻读博士学位（李佳琪），1名硕士已被中国药科大学录取攻读博士学位（郑文鸽），1名硕士已被湖南大学录取攻读博士学位。
姓名 |
年级 |
深造情况 |
王珂欣 |
2021级毕业生 |
南方医科大学（博士后） |
李佳琪 |
2019级毕业生 |
澳门科技大学（博士） |
郑文鸽 |
2021级毕业生 |
中国药科大学（博士） |
杨吾燕 |
2022级毕业生 |
湖南大学（博士） |