高丽，博士，副教授，硕士生导师，“三晋英才”青年优秀人才，研究方向为神经药理学及抗衰老研究。主持国家自然科学青年基金1项、中国博士后科学基金面上项目1项、山西省重点研发计划（社发领域）项目1项、其他省部级项目5项，以第一作者和通讯作者发表学术论文30余篇，SCI论文28篇,其中SCI一区论文2篇，SCI二区论文14篇，代表性杂志Ageing Research Reviews （IF:13.1）、Phytomedicine（IF: 7.9）、ACS chemical neuroscience等。兼任中国药理学会网络药理学专业委员会委员，中国药理学会中药及天然药物委员会委员，中国研究型医院学会神经再生与修复专业委员会委员。
工作经历：
2017/12-至今：山西大学中医药现代研究中心，副教授
2014/07-2017/12: 山西大学中医药现代研究中心，讲师
教育经历：
2009/09—2014/07: 北京协和医学院药物研究所，药理学专业，硕博连读，导师：杜冠华教授 刘艾林教授
2005/09-2009/07: 沈阳药科大学，药学院，药学专业，理学学士
研究方向：神经药理学、抗衰老研究
硕士招生专业：药学、中药学
联系方式：Email: gaoli87@sxu.edu.cn 电话：13623639072
承担科研项目（主持）：
(1) 国家自然科学青年基金，81603319，基于基因网络调控的黄芩素改善衰老性学习记忆障碍作用机制研究，2017.01-2019.12，经费18万，结题，主持。
(2) 中国博士后科学基金第72批面上项目，基于钠离子通道 Nav1.7 研究复方苦参注射液治疗癌性疼痛的显效成分和作用机制，2023.1-2024.12，经费8万元，在研，主持。
(3) 山西省基础研究计划自然科学研究面上项目，基于基因调控布尔网络研究黄芩素抑制衰老相关分泌表型（SASP）改善衰老性认知功能障碍的机制，2023.1-2025.12，经费10万元，在研，主持。
(4) 山西省重点研发计划（社发领域）项目，201903D321216，经典方剂黄芩汤治疗帕金森病的新功效研发，2019.12.01-2021.12.01，经费5万，主持。
(5) 山西省面上青年基金项目，201801D221374，黄芩素调控基因网络改善SAMP8快速老化小鼠学习记忆障碍机制研究，2018.12-2020.12，经费3万，在研，主持。
(6) 山西省研究生联合培养基地人才项目，2016JD05，基于网络药理学的复方苦参注射液治疗肝癌作用机制研究，经费3万，结题，主持。
(7) 山西省高等学校科技创新项目，2015118，基于药物-靶点网络的黄芩单体成分抗衰老活性研究，2015.03-2017.03，经费3万，结题，主持。
(8) 山西省研究生教育改革项目，2019JG029，《实验设计与医药统计》教学改革与实践探索，2019.07.01-2022.06.22，经费1万，结题，主持。
(9) 横向项目，基于代谢组学研究丹酚酸A防治脑缺血的作用及机制，5万元，2021.01-2022.12，在研，主持。
(10) 横向项目，基于代谢组学研究中药复方防治脑病的作用及机制，7.5万元，2021.01-2022.12，在研，主持
专著：
[1] 杜冠华译，王月华，刘艾林, 高丽（参编）. 药理学原理，人民卫生出版社, 2023.
[2] 杜冠华, 陈乃宏, 陈忠, 方莲花, 秦雪梅, 高丽（参编）. 实验药理学，高等教育出版社, 2021.
[3] 黄璐琦, 屠鹏飞, 高晓燕，张媛，秦雪梅，高丽（参编）. 新编中国药材学， 中国医药科技出版社，2020.
[4] 杜冠华, 张均田, 方莲花, 吕扬, 陈乃宏, 王金华, 秦雪梅, 高丽（参编）. 天然小分子药物, 人民卫生出版社, 2018.
[5] 王喜军，韩莹，孙晖，闫广利，秦雪梅，高丽（参编）. 中医方证代谢组学研究进展, 科学出版社, 2018.
获奖：
[1] 王秀伶，于秀梅，赵慧，梁晓琳，高丽. 大豆异黄酮微生物转化产物的有氧合成调控及其抗癌作用机制，河北省自然科学三等奖，2021.
代表性论文：
[1] Yi-xiao Dong, Kun-kun Zhao, Xue-mei Qin, Guanhua-Du*, Li Gao*. The mechanisms of perineuronal net abnormalities in contributing aging and neurological diseases. Ageing Research Reviews. 2023, 92:102092. (SCI 1区，TOP，IF：13.1）
[2] Li Gao*, Wu-yan Yang, Hong Qi, Chang-jun Sun, Xue-mei Qin, Guan-hua Du*. Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low glucose-induced astrocytes based on boolean network. Phytomedicine, 2022, 99:153990. （SCI 2区，TOP）
[3] Li Gao*, Min Cao, Guan-hua Du, Xue-mei Qin*. Huangqin Decoction Exerts Beneficial Effects on Rotenone-Induced Rat Model of Parkinson's Disease by Improving Mitochondrial Dysfunction and Alleviating Metabolic Abnormality of Mitochondria. Frontiers in Aging Neuroscience, 2022, 14: 911924. （SCI 2区）
[4] Ke-Xin Wang, Guan-hua Du, Xue-mei Qin*, Li Gao*. 1H-NMR-based metabolomics reveals the biomarker panel and molecular mechanism of hepatocellular carcinoma progression. Analytical and Bioanalytical Chemistry, 2022, 414(4): 1525-1537. (SCI 3区）
[5] Ke-Xin Wang, , Xiang-min Ye, Chuanhui Yin, Qing Ren, Yupeng Chen, Xuemei Qin, Chuanzhi Duan, Aiping Lu*, Li Gao* and Daogang Guan*. Computational Metabolomics Reveals the Potential Mechanism of Matrine Mediated Metabolic Network Against Hepatocellular Carcinoma. Frontiers In Cell And Developmental Biology, 2022, 10:859236. （SCI 2区）
[6] Ke-Xin Wang, Guan-Hua Du, Xue-Mei Qin*, Li Gao*. Compound Kushen Injection intervenes metabolic reprogramming and epithelial-mesenchymal transition of HCC via regulating β-catenin/c-Myc signaling. Phytomedicine, 2021, 93:153781. (SCI 2区，TOP，IF: 5.34)
[7] Li Gao*, Wen-ge Zheng, Xing-kang Wu, Guanhua Du, Xuemei Qin*. Baicalein Delays H2O2-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism. ACS chemical neuroscience, 2021, 12(13):2320-2335. (SCI 2区，IF: 4.42)
[8] Ke-Xin Wang, Yu-Peng Chen, Ai-Ping Lu, Guan-Hua Du, Xue-Mei Qin*, Dao-Gang Guan*, Li Gao*. A metabolic data-driven systems pharmacology strategy for decoding and validating the mechanism of Compound Kushen Injection against HCC. Journal of Ethnopharmacology, 2021, 274:114043. (SCI 3区，IF: 4.36)
[9] Ke-Xin Wang, Kai Li, Yu-Peng Chen, Gen-Xia Wei, Hai-lang Yu, Yi Li, Wei Meng, Handuo Wang , Li Gao*, Aiping Lu, Junxiang Peng, Daogang Guan. Computational Network Pharmacology-Based Strategy to Capture Key Functional Components and Decode the Mechanism of Chai-Hu-Shu-Gan-San in Treating Depression. Frontiers in Pharmacology, 2021, 12: 782060. (SCI 2区)
[10] Li Gao*, Min Cao, Jia-Qi Li, Xue-Mei Qin, Jiansong Fang*. Traditional Chinese Medicine Network Pharmacology in Cardiovascular Precision Medicine. Current Pharmaceutical Design. 2021, 27(26): 2925-2933.
[11] Jiaqi Li, Jiansong Fang, Xuemei Qin*, Li Gao*. Metabolomics profiling reveals the mechanism of caffeic acid in extending lifespan in Drosophila melanogaster. Food Funct, 2020, 11(9): 8202-8213. (SCI 1区)
[12] Kexin Wang#; Yao Gao#; Cheng Lu; Yao Li; Bo-ya Zhou; Xue-mei Qin; Guanhua Du; Li Gao*; Daogang Guan*; Ai-ping Lu*; Uncovering the Complexity Mechanism of Different Formulas Treatment for Rheumatoid Arthritis Based on a Novel Network Pharmacology Model. Front Pharmacol, 2020, 11:1035. (SCI 2区)
[13] Li Gao*, Feng Zhou, Ke-xin Wang, Yuzhi Zhou, Guanhua Du, Xuemei Qin*. Baicalein protects PC12 cells from Aβ25-35-induced cytotoxicity via inhibition of apoptosis and metabolic disorders. Life Sciences, 2020, 248:117471. (SCI 3区)
[14] Jiao-jiao Yan, Guan-hua Du, Xue-mei Qin*, Li Gao*. Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality. International Immunopharmacology, 2020, 79:106092. (SCI 3区)
[15] Ke-xin Wang, Jian-song Fang, Xue-mei Qin, Guan-hua Du⁎, Li Gao⁎, Uncovering the anti-metastasis effects and mechanisms of capsaicin against hepatocellular carcinoma cells by metabolomics. Journal of Functional Foods. 2019, 60: 103431. (SCI 2区,TOP)
[16] Jiaqi Li, Dandan Duan, Jianqin Zhang, Yuzhi Zhou, Xuemei Qin, Guanhua Du⁎, Li Gao⁎, Bioinformatic prediction of critical genes and pathways involved in longevity in Drosophila melanogaster. Molecular Genetics and Genomics. 2019, 294:1463–1475. (SCI 3区)
[17] Jia-qi Li, Yu-zhi Zhou, Guan-hua Du, Xue-mei Qin, Li Gao*. Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8). European Journal of Pharmacology. 2019, 865: 172789. (SCI 3区)
[18] Li Gao#*, Jia-Qi Li#, Yu-Zhi Zhou, Xu-Dong Huang, Xue-Mei Qin, Guan-Hua Du. Effects of Baicalein on Cortical Proinflammatory Cytokines and the Intestinal Microbiome in Senescence Accelerated Mouse Prone 8. ACS Chem Neurosci. 2018, 9(7):1714-1724. (SCI 2区,TOP)
[19] Li Gao#*, Ke-Xin Wang#, Nan-Nan Zhang#, Jia-Qi Li, Xue-Mei Qin, Xiu-Ling Wang*. 1H Nuclear Magnetic Resonance Based Metabolomics Approach Reveals the Metabolic Mechanism of (-)-5-Hydroxy-equol against Hepatocellular Carcinoma Cells in Vitro. Journal of proteome research, 2018, 17(5): 1833-1843. (SCI 2区)
[20] Li Gao#*, Ke-Xin Wang#, Yu-Zhi Zhou, Jian-Song Fang, Xue-Mei Qin*, Guan-Hua Du. Uncovering the anticancer mechanism of Compound Kushen Injection against HCC by integrating quantitative analysis, network analysis and experimental validation. Scientific reports, 2018, 8(1): 624. (SCI 3区)
[21] Jia-qi Li, Yu-zhi Zhou, Guan-hua Du, Xue-mei Qin, Li Gao*. Bioinformatic Analysis Reveals Key Genes and Pathways in Aging Brain of Senescence-accelerated Mouse P8 (SAMP8). CNS Neurol Disord Drug Targets. 2018, 17(9):712-722. (SCI 3区)
[22] Dan-Dan Duan, Ke-Xin Wang, Yu-Zhi Zhou, Xue-Mei Qin*, Li Gao*, Guan-Hua Du. Baicalein Exerts Beneficial Effects in d-Galactose-Induced Aging Rats Through Attenuation of Inflammation and Metabolic Dysfunction. Rejuvenation Research, 2017, 20(6): 506-516. (SCI 2区)
[23] Li Gao&, Xiao-Dong Wang&, Yang-Yang Niu&, Dan-Dan Duan, Xue Yang, Jian Hao, Cui-Hong Zhu, Dan Chen, Ke-Xin Wang, Xue-Mei Qin, Xiong-Zhi Wu*. Molecular targets of Chinese herbs: a clinical study of hepatoma based on network pharmacology. Scientific Reports, 2016, 6:24944. (SCI 2区)
[24] Li Gao, Dan-Dan Duan, Jian-Qin Zhang, Yu-Zhi Zhou, Xue-Mei Qin*, Guan-Hua Du*. A bioinformatic approach for discovery of the anti-aging effects of baicalein from Scutellaria baicalensis Georgi. Rejuvenation Res, 2016, 19(5): 414-422. (SCI 3区)
[25] Li Gao#, Jian Hao#, Yang-Yang Niu, Miao Tian, Xue Yang, Cui-Hong Zhu, Xiu-Li Ding, Xiao-Hui Liu, Hao-Ran Zhang, MDb, Chang Liu, Xue-Mei Qin, Xiong-Zhi Wu*. Network pharmacology dissection of multiscale mechanisms of herbal medicines in stage IV gastric adenocarcinoma treatment [J]. Medicine (Baltimore). 2016, 95(35): e4389. (SCI 2区)
[26] Li Gao, Chao Li, Ran-Yao Yang, Wen-Wen Lian, Jian-Song Fang, Xiao-Cong Pang, Xue-Mei Qin, Ai-Lin Liu*, Guan-Hua Du*. Ameliorative effects of baicalein in MPTP-induced mouse model of Parkinson's disease: A microarray study. Pharmacol Biochem Behav, 2015, 133: 155-163. (SCI 3区)
[27] Li Gao, Gang Zhao, Jian-Song Fang, Tian-Yi Yuan, Ai-Lin Liu*, Guan-Hua Du*. Discovery of the neuroprotective effects of alvespimycin by computational prioritization of potential anti-parkinson agents. FEBS Journal, 2014, 281(4): 1110-1122. (SCI 2区)
[28] Li Gao, Jian-Song Fang, Xiao-Yu Bai, Dan Zhou, Yi-Tao Wang, Ai-Lin Liu*, Guan-Hua Du*. In silico target fishing for the potential targets and molecular mechanisms of baicalein as an anti-parkinsonian agent: discovery of the protective effects on NMDA receptor-mediated neurotoxicity. Chemical Biology & Drug Design, 2013, 81(6):675-687. (SCI 3区)
[29] Li Gao, Mian Zu, Song Wu, Ai-Lin Liu*, Guan-Hua Du*. 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. Bioorganic & Medicinal Chemistry Letters, 2011, 21(19): 5964-5970. (SCI 3区)
培养研究生情况:
目前累计培养研究生10余名，其中毕业6人，在读6人。1名硕士转博，目前已博士毕业（王珂欣），1名硕士毕业后被澳门科技大学录取攻读博士学位（李佳琪），1名硕士已被中国药科大学录取攻读博士学位（郑文鸽），1名硕士已被湖南大学录取攻读博士学位。
姓名 |
年级 |
深造情况 |
王珂欣 |
2021级毕业生 |
南方医科大学（博士后） |
李佳琪 |
2019级毕业生 |
澳门科技大学（博士） |
郑文鸽 |
2021级毕业生 |
中国药科大学（博士） |
杨吾燕 |
2022级毕业生 |
湖南大学（博士） |